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师资队伍

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>>师资队伍 >>按系别 >>动物遗传育种系

李孟华

发布时间:2022-04-15 访问次数: 信息来源:动物科技学院 字号:[大 中 小]

姓名: 李孟华

职称: 教授

所在系: 动物遗传育种系


研究方向: 绵羊遗传与种质创新

办公电话: 010-62731006

电子邮箱: menghua.li@cau.edu.cn

个人简介

李孟华,中国农业大学,教授,博士生导师;中国农业大学领军教授(A类,2020年)、国家级创新团队负责人(2020年);中国科学院“百人计划”(A类, 2011年),国家杰出青年基金获得者(2018年)。主要从事“绵羊遗传与种质创新方向”研究,已在Nature Communications, Current Biology, Molecular Biology and Evolution等专业期刊发表论文50余篇。目前承担国家自然科学基金和国家重点研发计划等科研项目。

(二)工作经历

1.    2003年博士毕业于华中农业大学畜牧兽医学院动物遗传育种与繁殖专业;

2.    2003年-2010年先后在芬兰农业食品科学研究院、赫尔辛基大学从事博士后研究,其间受欧盟邀请任挪威生命科学技术大学和意大利米兰圣心天主教大学短期访问学者; 

3.    2010年至2011年任芬兰农业食品科学研究院研究员(PI); 

4.    2011年-2019年任中国科学院动物研究所研究员。被授予赫尔辛基大学副教授/兼职教授(Docent,2010年6月),入选芬兰科学院研究员(Research Fellow of the Academy of Finland, 2011年)。

担任国际动物遗传学会羊专业委员会主席(2019年8月-),Animal Genetics等SCI杂志编委以及第一届(2017年)、第二届(2018年)和第三届(2020)“世界绵羊大会”主席。获“欧洲科学基金-生命、地球、环境和极地科学部”青年科学奖(2011年)。

(四)科研工作

论文及著作:

(#为共同第一作者,*为通讯作者)

2020年度: 

1.    Pokharel K, Peippo J, Weldenegodguad M, Honkatukia M, Li M-H* & Kantanen J (2020) Gene expression profiling of corpus luteum reveals important insights about early pregnancy in domestic sheep. Genes 11: 415. 

2.    Pokharel K, Peippo J, Li M-H* & Kantanen J (2020) Functional profiling of endometrium transcriptome during preimplantation development in Finnsheep, Texel and their F1 crosses. Agricultural and Food Science 29: 331-345. 

3.    Pokharel K, Peippo J, Li M-H* & Kantanen J (2020) Identification and characterization of miRANs during early pregnancy in domestic sheep. Animal Genetics 51: 833-836. 

4.   Xin Li#, Ji Yang#, Min Shen#, Xing-Long Xie#, Guang-Jian Liu#, Ya-Xi Xu, Feng-Hua Lv, Hua Yang, Yong-Lin Yang, Chang-Bin Liu, Ping Zhou, Peng-Cheng Wan, Yun-Sheng Zhang, Lei  Gao, Jing-Quan Yang, Wen-Hui Pi, Yan-Ling Ren, Zhi-Qiang Shen, Feng Wang,   Juan Deng, Song-Song Xu, Hosein Salehian-Dehkordi, Eer Hehua, Ali Esmailizadeh,   Mostafa Dehghani-Qanatqestani, Ondřej Štěpánek, Christina Weimann, Georg Erhardt, Agraw Amane, Joram M   Mwacharo, Jian-Lin Han, Olivier Hanotte, Johannes A Lenstra, Juha Kantanen,   David W Coltman, James W Kijas, Michael W Bruford, Kathiravan Periasamy,   Xin-Hua Wang*, Meng-Hua Li* (2020) Whole-genome resequencing of wild and domestic sheep   identifies genes associated with morphological and agronomic traits. Nature Communications 11:2815.

5.   Yin-Hong Cao#, Song-Song Xu#, Min Shen#, Ze-Hui Chen#, Lei Gao#, Feng-Hua Lv, Xing-Long Xie, Xin-Hua Wang, Hua Yang, Chang-Bin Liu, Ping Zhou, Peng-Cheng Wan, Yun-Sheng Zhang, Jing-Quan Yang, Wen-Hui Pi, E Er Hehua, Donagh P Berry, Mario Barbato, Ali Esmailizadeh, Maryam Nosrati, Hosein Salehian-Dehkordi, Mostafa Dehghani-Qanatqestani, Arsen V Dotsev, Tatiana E Deniskova, Natalia A Zinovieva, Gottfried Brem, Ondřej Štěpánek, Elena Ciani, Christina Weimann, Georg Erhardt, Joram M Mwacharo, Abulgasim Ahbara, Jian-Lin Han, Olivier Hanotte, Joshua M Miller, Zijian Sim, David Coltman, Juha Kantanen, Michael W Bruford, Johannes A Lenstra, James Kijas, Meng-Hua Li* (2020) Historical Introgression from Wild Relatives Enhanced Climatic Adaptation and Resistance to Pneumonia in Sheep, Molecular Biology and Evolution, msaa236, https://doi.org/10.1093/molbev/msaa236.

6.   Juan Deng#, Xing-Long Xie#, Dong-Feng Wang, Chao Zhao, Feng-Hua Lv, Xin Li, Ji Yang, Jia-Lin Yu, Min Shen, Lei Gao, Jing-Quan Yang, Ming-Jun Liu, Wen-Rong Li, Yu-Tao Wang, Feng Wang, Jin-Quan Li, EEr Hehua, Yong-Gang Liu, Zhi-Qiang Shen, Yan-Ling Ren, Guang-Jian Liu, Ze-Hui Chen, Neena A. Gorkhali, Hossam E. Rushdi, Hosein Salehian Dehkordi, Ali Esmailizadeh, Maryam Nosrati, Samuel R. Paiva, Alexandre R. Caetano, Ondřej Štěpánek, Ingrid Olsaker, Christina Weimann, Georg Erhardt, Ino Curik, Juha Kantanen, Joram M. Mwacharo, Olivier Hanotte, Michael W Bruford, Elena Ciani, Kathiravan Periasamy, Marcel Amills, Johannes A Lenstra, Jian-Lin Han, Hong-Ping Zhang, Li Li, Meng-Hua Li* (2020) Paternal Origins and Migratory Episodes of Domestic Sheep. Current Biology 30:4085-4095.

2019年度:

7.    Xiao-Ju Hu#, Ji Yang#, Xing-Long Xie#, Feng-Hua Lv#, Yin-Hong Cao ,Wen-Rong Li, Ming-Jun Liu, Yu-Tao Wang, Jin-Quan Li, Yong-Gang Liu,Yan-Lin Ren, Zhi-Qiang Shen, Feng Wang, EEr Hehua, Jian-Lin Han, Meng-Hua Li* (2019) The genome landscape of Tibetan sheep reveals adaptive introgression   from argali and the history of early human settlements on the Qinghai-Tibetan   Plateau. Molecular Biology and Evolution 36:283-303.

8.    Ji Yang(#), Xin   Li(#), Yin-Hong Cao(#), Kisun Pokharel(#), Xiao-Ju Hu(#), Ze-Hui Chen(#),   Song-Song Xu, Jaana Peippo, Mervi Honkatukia, Juha Kantanen, Meng-Hua Li* (2019)Comparative mRNAs   and miRNAs expression in European mouflon (Ovis musimon) and sheep (Ovis   aries) provide novel insights into the genetic mechanisms for female   reproductive success. Heredity   122: 172–186.

2018年度: 

9.    Lei Gao(#), Song-Song Xu(#), Jing-Quan Yang(#),   Min Shen*, Meng-Hua Li* (2018) Genome-wide association study reveals   novel genes for the ear size in sheep (Ovis aries). Animal   Genetics 49:345-348.

10.    Ze-Hui Chen(#), Min Zhang(#), Feng-Hua Lv(#), Xue Ren, Wen-Rong Li, Ming-Jun Liu, Kiwoong Nam, Michael W   Bruford, Meng-Hua Li* (2018)   Contrasting patterns of genomic diversity reveal accelerated genetic drift   but reduced directional selection on X-chromosome in wild and domestic sheep   species. Genome Biology and Evolution 10:1282-1297.

11.    Song-Song Xu(#), Lei Gao(#), Xing-Long Xie, Yan-Ling Ren, Zhi-Qiang Shen, Feng Wang, Min Shen, Emma Eyporsdottir, Jon H. Hallsson,Tatyana Kiseleva, Juha Kantanen and Meng-Hua Li* (2018)   Genome-wide association analyses highlight the potential for different   genetic mechanisms for litter size among sheep breeds. Frontier in   Genetics (Livestock genomics) 9:118.

12.    Pokharel Kisun,   Peippo Jaana, Honkatukia Mervi, Seppala Arja, Rautiainen Johanna, Ghanem   Nasser, Hamama Tuula-Marjatta, Crowe Mark A, Andersson Magnus, Li Meng-Hua*, Kantanen Juha*(2018) Integrated ovarian mRNA and miRNA   transcriptome profiling characterizes the genetic basis of prolificacy traits   in sheep (Ovis aries). BMC Genomics 19:104.

2017年度:

13.    Zhao   Yong-Xin(#),Yang Ji(#), Lv Feng-Hua(#),Hu Xiao-Ju, Xie Xing-Long, Zhang Min,   Li Wen-Rong, Liu Ming-Jun, Wang Yu-Tao, Li Jin-Quan, Liu Yong-Gang, Ren Yan-Ling,   Wang Feng, Eer Hehua,  Kantanen, Juha   Lenstra, Johannes Arjen, Han Jian-Lin, Li Meng-Hua* (2017) Genomic   reconstruction of the history of native sheep reveals the peopling patterns   of nomads and the expansion of early pastoralism in East Asia. Molecular Biology and Evolution 34:2380-2395.

14.    Xu Song-Song#,   Ren Xue#, Yang Guang-Li#, Xie Xing-Long, Zhao Yong-Xin, Zhang Min, Shen   Zhi-Qiang, Ren Yan-Ling, Gao Lei, Shen Min, Juha Kantanen and Meng-Hua Li*   (2017) Genome-wide association analysis identifies the genetic basis of fat   deposition in the tails of sheep (Ovis aries). Animal Genetics 48:560-569.

15.    Peng W. -F.(#), Xu S. -S.(#),Ren X.(#),Lv F. -H., Xie   X. -L., Zhao  Y. -X., Zhang M., Shen Z.   -Q., Ren Y. -L., Gao L.,Shen M., Kantanen J., Li M.-H.* (2017) A   genome-wide association study reveals candidate genes for the supernumerary   nipple phenotype in sheep (Ovis aries). Animal Genetics 48:570-579.

2016年度:

16.    Ji Yang#, Wen-Rong Li#, Feng-Hua Lv#, San-Gang He#,   Shi-Lin Tian#, Wei-Feng Peng, Ya-Wei Sun, Yong-Xin Zhao, Xiao-Long Tu, Min   Zhang, Xing-Long Xie, Yu-Tao Wang, Jin-Quan Li, Yong-Gang Liu, Zhi-Qiang   Shen, Feng Wang, Guang-Jian Liu, Hong-Feng Lu, Juha Kantanen, Jian-Lin Han, Meng-Hua Li* and Ming-Jun Liu*(2016)Whole-Genome Sequencing of Native Sheep Provides Insights into   Rapid Adaptations to Extreme Environments. Molecular Biology and Evolution 33(10): 2576–2592.

· 封面文章

· 受到“International Livestock Research Institute (ILRI)”点评和报道

17.    Xiao-ju Hu, Kisun Pokharel,Jaana Peippo, Nasser Ghanem,Ismael   Zhaboyev,Juha Kantanen and Meng-Hua Li* (2016)Identification   and characterization of miRNAs in the ovaries of a highly prolific sheep   breed. Animal Genetics 47:234-239.

2015年度: 

18.    Lv F-H, Peng W-F, Yang J, Zhao Y-X, Li W-R, Liu M-J, Ma   Y-H, Zhao Q-J, Yang G-L, Wang F, Li J-Q, Liu Y-G, Shen Z-Q, Zhao S-G, Hehua   E, Gorkhali NA, Farhad Vahidi SM, Muladno M, Naqvi AN, Tabell J, Iso-Touru T,   Bruford MW, Kantanen J, Han J-L*, Li M-H* (2015). Mitogenomic Meta-Analysis Identifies Two Phases of Migration in the History of Eastern   Eurasian Sheep. Molecular Biology and Evolution 32: 2515-2533.

· 封面文章

· 受到“Financial Times”,“Modern Farmer”和“ILRI”等媒体报道和点评

· 受到《中国科学》的评述

· 中国科学院科研进展英文评述

19.    Feng-Hua Lv,   Saif Agha, Juha Kantanen, LiciaColli, Sylvie Stucki, James W. Kijas, Stéphane Joost, Meng-Hua Li*, Paolo Ajmone Marsan   (2014) Adaptations to Climate-Mediated Selective Pressures in Sheep.   Molecular Biology and Evolution 31: 3324-3343.

· 封面文章

· 受到Science daily等媒体报道和点评

20.    Shan L., Wu Q., Li Y., Shang H., Guo K., Wu J., Wei H., Zhao J., Yu J., Li M.-H.* (2014) Transcriptome profiling identifies   differentially expressed genes in postnatal developing pituitary gland of   miniature pig. DNA Research 21:207-216.

21.    Li M.-H.*, T. Tiirikka, J. Kantanen (2014) A genome-wide scan study identifies a single   nucleotide substitution in ASIP associated with white versus non-white   coat-colour variation in sheep (Ovis aries). Heredity   112: 122–131.

22.    Zhang Min, Wei-Feng Peng, Guang-Li Yang, Feng-Hua Lv,   Ming-Jun Liu, Wen-Rong Li, Yong-Gang Liu, Jin-Quan Li, Feng Wang, Zhi-Qiang   Shen, Sheng-Guo Zhao, EEr Hehua, Nurbiy Marzanov, Maziek Murawski, Juha   Kantanen and Meng-Hua Li (2014) Y chromosome haplotype diversity of   domestic sheep (Ovis aries) in northern Eurasia. Animal Genetics   45:903-907

2011-2013年度:

23.    Wang C., Hu X., Xie X., Liu P., Merilä J., Zhang Q. *, Li M.-H.* (2013) Isolation and characterization of 113 polymorphic   microsatellite loci for the Tibetan frog (Nanorana parkeri) using next   generation sequencing. Conservation Genetics Resources 5:   915-924.

24.    Li M.-H., A.Osva,   J. Kantanen (2012) Integrating multidisciplinary data for the conservation of   livestock biodiversity: a case study of the Yakutian cattle in Siberia, the   far east of Russia. Animal Genetics Resources 50:97-104.

25.    Li M. H.* and J.   Merilä (2011) Population differences in levels of linkage disequilibrium in   the wild. Molecular Ecology 20: 2916-2928.

26.    Li M.-H., I.   Strandén, T. Tiirikka, M.-L. Sevón-Aimonen, J. Kantanen (2011) A comparison of approaches to   estimate the inbreeding coefficient and pairwise relatedness using genomic   and pedigree data in a sheep population. PLoS ONE 6: e26256.

27.    Cano J.M., M.-H. Li, Laurila A, Vilkki J, Merilä   J. (2011) First-generation linkage map for the common frog Ranatemporaria   reveals sex linkage group. Heredity 107: 530-536.

28.    Li M.-H.*, J. Kantanen, A. Michelson, U. Saarma (2011) Genetic components of grey cattle in   Estonia as revealed by microsatellite analysis using two Bayesian clustering   methods. BMC Research Notes 4: 37.

29.    Zerabruk M.#, Li M.-H. #, J. Kantanen, I.   Olsaker, E. M. Ibeagha-Awemu, G. Erhardt, D. G. Bradley and O Vangen (2011)   Genetic diversity and admixture of indigenous cattle breeds of North   Ethiopia: implications to historical introgressions in the gateway region of   cattle to Africa. Animal Genetics 43:257-266.

30.    Nair A., S. Kumar, S. George, S. Gopalan, M.-H. Li,   E. Leder and J. Merilä (2011) Sixty two new microsatellite markers for an   endemic frog Indirana beddomii from the Western Ghats biodiversity   hotspot. Conservation Genetics Resources 3: 167-171.

2001-2010年度:

31.    Tapio, I., Tapio, M., M.-H. Li, Popov, R.,   Ivanova, Z., Kantanen, J (2010) Estimation of relatedness among non-pedigreed   Yakutiancryo-bank bulls using molecular data: implications for conservation   and breed management. Genetics Selection Evolution 42: 9.

32.    Li M. H.* and J.   Merilä (2010) Genetic evidence for male-biased dispersal in the Siberian jay   (Perisoreus infaustus) based on autosomal and Z chromosomal markers. Molecular   Ecology 19: 5281-5295.

33.    Li, M.H.,   Kantanen, J (2010) Genetic structure of Eurasian cattle (Bos taurus)   based on microsatellites: clarification for their breed classification.   Animal Genetics 41: 150-158.

34.    Li, M.H.,   Iso-Touru, T., Lauren, H., Kantanen, J (2010) A microsatellite-based analysis   for the detection of selection on BTA1 and BTA20 in northern Eurasian cattle   (Bos taurus) populations. Genetics Selection Evolution   42: 14.

35.    Li M. H.* and J.   Merilä (2010) Avian Z-specific microsatellites map to pseudoautosomal or   autosomal chromosomes in the Siberian jay (Perisoreus infaustus):   insights into avian genome evolution from cross-species amplification tests. Journal of Genetics 89: 223-228.

36.    Li M.-H.* and J.   Merilä (2010) Sex-specific population structure, natural selection, and   linkage disequilibrium in a wild bird population as revealed by genome-wide   microsatellite analyses. BMC Evolutionary Biology 10: 66.

· 受到 Science (328:19)“编辑的选择”栏目评述

37.    Li M.-H.*, and J.   Merilä (2010) Extensive linkage disequilibrium in a wild bird population. Heredity   104: 600-610.

38.    Iso-Touru, T., J. Kantanen, M. H. Li, Z.   Gizejewski and J.Vilkki (2009) Divergent evolution in cattle and pigs in the   cytoplasmic domains of GHR and PRLR. BMC Evolutionary Biology   9:172.

39.    Li M.-H.*, K.   Välimäki, M. Piha, T.Pakkala and J. Merilä (2009) Extrapair paternity   and maternity in the three-toed woodpecker, Picoides tridactylus:   insights from microsatellite-based parentage analysis. PLoS ONE   4: 1-6.

40.    Li M.-H.*, I.   Strandén, and J. Kantanen (2009) Genetic   diversity and pedigree analysis of the Finnsheep breed. Journal of Animal Science 87:1598-1605.

41.    Jarri S., M.-H. Li, and J. Merilä (2009) A   first-generation microsatellite-based genetic linkage map of the Siberian jay   (Perisoreus infaustus): insights into avian genome evolution. BMC Genomics 10: 1.

42.    Agha S. H., F. Pilla, S. Galal, I. Shaat, M. D’Andrea, S. Reale, A. Z. A. Abdelsalam, and M.-H. Li (2008) Genetic diversity in Egyptian and Italian goat breeds measured with   microsatellite polymorphism. Journal of Animal Breeding and Genetics   125: 194-200.

43.    Li M.-H., I.   Tapio, J. Vilkki, Z. Ivanova, T. Kiselyova, N. Marzanov, M. Cinkulov, S.   Stojanovic, I. Ammosov, R. Popov, and J. Kantanen (2007) Genetic structure of   cattle populations (Bos taurus) in northern Eurasia and the   neighboring Near Eastern regions: implications for breeding strategies and  conservation. Molecular Ecology 16:3839-3853.

· 封面文章

44.    Li M.-H., M.   Zerabruk, O. Vangen, I. Olsaker, and J. Kantanen (2007) Reduced genetic   structure of north Ethiopian cattle revealed by Y-chromosome analysis. Heredity   98: 214-221.

45.    Li M.-H., T.   Adamowicz, M. Switonski, I. Ammosov, Z. Ivanova, T. Kiselyova, R. Popov, and   J. Kantanen (2006) Analysis of population differentiation in North Eurasian   cattle (Bos taurus) using single nucleotide polymorphisms in three   genes associated with production traits. Animal Genetics 37:   390-392.

46.    Bennewitz J., J. Kantanen, I. Tapio, M.-H. Li, E. Kalm, J. Vilkki, I.   Ammosov, Z. Ivanova, T. Kiselyova, R. Popov, and T. H. Meuwissen (2006)   Estimation of breed contributions to present and future genetic diversity of   44 North Eurasian cattle breeds using core set diversity measures. Genetics Selection Evolution 38: 201-220.

47.    Li M.-H., K. Li,   J. Kantanen, Z. Feng, B. Fan, and S. H. Zhao (2006) Allelic variations in   exon 2 of caprine MHC class II DRB3 gene in Chinese indigenous goats. Small  Ruminant Research 66: 236-243.

48.    Li M.-H., E.   Nogovitsina, Z. Ivanova, G. Erhardt, J. Vilkki , R. Popov, I. Ammosov, T.   Kiselyova, and J. Kantanen (2005) Genetic contributions of indigenous   Yakutian cattle to two hybrid populations as revealed by microsatellite   variation. Asian-Australasian Journal of Animal Sciences 18:   613-1619.

49.    Li, M.-H., K.   Sternbauer, P. T. Haahr, and J. Kantanen (2005) Genetic components in   contemporary Faroe Islands Cattle as revealed as microsatellite analysis.   Journal of Animal Breeding and Genetics 122: 309-317.

50.    Li S. J., S. H, Yang, S. H. Zhao, B. Fan, M. Yu, H. S.   Wang, M.-H. Li, B. Liu, T. A. Xiong, and K. Li (2004) Genetic   diversity analyses of 10 indigenous Chinese pig populations based on 20   microsatellites. Journal of Animal Science 82:368-374.

51.    Li M.-H., S, H.   Zhao, and K. Li (2004) Diversity of Chinese indigenous goat breeds: a   conservation perspective – a review.   Asian-Australasian Journal of Animal Sciences 17: 726-732.

52.    Mo D. L., B. Liu, Z. G. Wang, S. H. Zhao, M. Yu, B.   Fan, M.-H. Li, T. A. Xiong, M. Yu, and K. Li (2003) Genetic variation   and genetic relationship of seventeen Chinese indigenous pig breeds using ten   serum protein loci. Asian-Australasian Journal of Animal Sciences   16: 939-945.

53.    Yang S. L, Z. G Wang, B. Liu, G. X. Zhang, S. H. Zhao,   M. Yu, B. Fan, M.-H. Li, and K. Li (2003) Genetic variation and   relationships of eighteen Chinese indigenous pig breeds. Genetics   Selection Evolution 35: 657-671.

54.    Fan B., Z. G. Wang, Y. J. Li, X. L. Zhao, B. Liu, S. H.   Zhao, M Yu, M.-H. Li, S. L. Chen, T.A. Xiong, and K. Li (2002) Genetic   variation analysis within and among Chinese indigenous swine populations   using microsatellite markers. Animal Genetics 33: 422-427.

55.    Li M.-H., S. H.   Zhao, C. Bian, H. S. Wang, H. Wei, B.Liu, M. Yu, B. Fan, S. L. Chen, M. J.   Zhu, T. A. Xiong, and K. Li (2002) Genetic relationships among twelve indigenous   Chinese goat populations based on microsatellite analysis. Genetics Selection Evolution 34: 729-744.

56.    Chen S. L., M.-H. Li, Y. J. Li, S.H. Zhao, C. Z.   Yu, M. Yu, B. Fan, T. A. Xiong, and K. Li (2001) RAPD variation and genetic   distances among Tibetan, Inner Mongolia and Liaoning Cashmere goats. Asian-Australasian   Journal of Animal Sciences 14: 1520-1522.

57.    Sakha Ynaga. Cattle of the Yakuts (Granberg L., J.   Kantanen& K. Soinieds). Finnish Academy of Science and Letters, Helsinki,   Finland. 218 pp. (ISBN978-951-41-1032-0, Li M.-H.是该书的主要的编著者之一).


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