畜禽育种国家工程实验室、农业农村部动物遗传育种与繁殖(家畜)重点实验室
青年学者系列报告-占贞贞
研究员
报告题目:炎症与疾病
时间: 2018年10月20号 上午11:00-12:00
地点: 动科楼0126报告厅
联系人:高帅 62734627
占贞贞,博士,现任同济大学附属东方医院心力衰竭研究所研究员,博导,兼医院科技办副主任。从事免疫炎症和自噬在缺血性心肺疾病、肿瘤以及感染性疾病中的作用研究。入选上海市卫生系统优秀学科带头人、上海市青年科技启明星,荣获中国免疫学青年学者奖、上海市卫生系统“银蛇奖”、中国百篇最具影响国际学术论文等荣誉。作为项目负责人主持国家自然科学基金5项、省部级课题4项等。
主要发表论文:
Yang L,
Wang B, Zhou Q, Wang Y, Liu X, Liu Z*, Zhan Z*. MicroRNA-21 prevents excessive inflammation and
cardiac dysfunction after myocardial infarction through targeting KBTBD7. Cell
Death Dis. 2018;9(7):769. Liu X,
Cao H, Li J, Wang B, Zhang P, Dong Zhang X, Liu Z, Yuan H*, Zhan Z*. Autophagy induced
by DAMPs facilitates the inflammation response in lungs undergoing
ischemia-reperfusion injury through promoting TRAF6 ubiquitination. Cell
Death Differ. 2017;24(4):683-693. Zhan Z*, Cao H, Xie X, Yang L, Zhang P, Chen Y, Fan
H, Liu Z, Liu X*. Phosphatase PP4 negatively regulates type I
interferon production and antiviral innate immunity by dephosphorylating and
deactivating TBK1. The Journal of Immunology. 2015 Oct 15;195(8):3849-3857. Zhan Z, Xie X, Cao H, Zhou X, Zhang XD, Fan H*, Liu
Z*. Autophagy facilitates TLR4- and TLR3-triggered migration and
invasion of lung cancer cells through the promotion of TRAF6 ubiquitination. Autophagy.
2014;10(2):257-268. Zhan Z, Li Q, Wu P, Ye Y, Tseng HY, Zhang L*, Zhang
XD*. Autophagy-mediated HMGB1 release antagonizes apoptosis of
gastric cancer cells induced by vincristine via transcriptional regulation of
Mcl-1. Autophagy. 2012;8(1):109-121. Liu X, Zhan Z, Li D, Xu L, Ma F, Zhang P, Yao
H, Cao X*. Intracellular MHC class II molecules promote TLR-triggered
innate immune responses by maintaining activation of the kinase Btk. Nature
Immunology. 2011;12(5):416-424. Liu X#,Zhan Z#, Xu L, Ma F, Li
D, Guo Z, Li N, Cao X*. MicroRNA-148/152 impair innate response and
antigen presentation of TLR-triggered dendritic cells by targeting CaMKIIα. The
Journal of Immunology. 2010;185(12):7244-7251.
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